Beyond depression: citalopram for
obsessive-compulsive disorder

by
Pato MT
Obsessive Compulsive Disorder Research and Treatment Program,
State University of New York at Buffalo,
Department of Psychiatry, 14203, USA.
Clin Neuropharmacol 1997 Oct; 20(5):419-33


ABSTRACT

Obsessive-compulsive disorder (OCD) and serotonin reuptake inhibitors became inextricably joined with the discovery of their effectiveness for the treatment of OCD in 1969 and 1976. The specificity of response of OCD to serotonin reuptake inhibitors has provided an important platform for the exploration of the neurobiology of OCD. This knowledge has come from many different areas of investigation, including neuroimaging, neuroimmunology and pharmacologic challenge studies. As the research into the pharmacologic treatment of OCD has progressed, a number of serotonin reuptake inhibitors have been approved and marketed for the treatment of OCD. These agents include clomipramine, sertraline, paroxetine, fluoxetine, and fluvoxamine. Because these agents share the same mechanism of action (serotonin reuptake inhibition), choosing which agent to use must be based on other parameters. These include differences in efficacy, dosing, and side-effect profile. Citalopram, a newly marketed selective serotonin reuptake inhibitor could offer some advantages over those agents currently marketed. Theoretically, it should also be effective in the treatment of OCD. In treating depression, it has been shown to have minimal side-effects, low risk of withdrawal symptoms, and little possibility of interaction with other agents.

OCD
Clomipramine
Sertraline and OCD
Citalopram and OCD
Alcohol and citalopram
Citalopram and ecstasy
SSRIs and panic disorder
Citalopram and selegiline
Citalopram v amitriptyline
Citalopram and depression
Citalopram and panic disorder
Serotonin and romantic lovers
Citalopram and eating disorders
Citalopram maintenance therapy
Citalopram and depression: trials
Citalopram: oral versus intravenous
Citalopram (Celexa, Cipramil) : structure
Citalopram as treatment of premature ejaculation
Citalopram (Celexa, Cipramil): prescribing information
Do atypical features affect outcome in depressed outpatients treated with citalopram?


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