Neuropharmacology of 5-hydroxytryptamine
by
Richard Green A.
1Global Discovery CNS and Pain Control,
AstraZeneca R&D Charnwood,
Bakewell Road, Loughborough LE11 5RH.
Br J Pharmacol. 2006 Jan;147 Suppl 1:S145-52.


ABSTRACT

S This review outlines the history of our knowledge of the neuropharmacology of 5-hydroxytryptamine (5-HT; serotonin), focusing primarily on the work of U.K. scientists. The existence of a vasoconstrictive substance in the blood has been known for over 135 years. The substance was named serotonin and finally identified as 5-HT in 1949. The presence of 5-HT in the brain was reported by Gaddum in 1954 and it was Gaddum who also demonstrated that the action of 5-HT (in the gut) was antagonised by the potent hallucinogen lysergic acid diethylamide. This provoked the notion that 5-HT played a pivotal role in the control of mood and subsequent investigations have generally confirmed this hypothesis. Over the last 50 years a good understanding has been gained of the mechanisms involved in control of the storage, synthesis and degradation of 5-HT in the brain. Knowledge has also been gained on control of the functional activity of this monoamine, often by the use of behavioural models. A considerable literature also now exists on the mechanisms by which many of the drugs used to treat psychiatric illness alter the functional activity of 5-HT, particularly the drugs used to treat depression. Over the last 20 years the number of identified 5-HT receptor subtypes has increased from 2 to 14, or possibly more. A major challenge now is to utilise this knowledge to develop receptor-specific drugs and use the information gained to better treat central nervous system disorders
SSRIs
Future anxiolytics
Serotonin research
MDMA neurotoxicity
21C antidepressants
The serotonin receptors
Serotonin and psychedelics
SNaRIs, NaSSAs, and NaRIs
Serotonin and romantic lovers
The monoamine theory of depression
Fluoxetine (Prozac): 10th Anniversary
Serotonin and the genetics of depression
Serotonin reuptake inhibitors v enhancers
Are SSRI antidepressants little better than placebos?
Selective serotonin reuptake inhibitors (SSRIs): binding profiles


Refs
and further reading

HOME
HedWeb
Nootropics
Cocaine.org
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family